Female antibodies to sperm

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Jump to content. An antisperm antibody test looks for special proteins antibodies that fight against a man's sperm in blood, vaginal fluids, or semen. The test uses a sample of sperm and adds a substance that binds only to affected sperm. Semen can cause an immune system response in either the man's or woman's body.
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Frequency of Antisperm Antibodies in Infertile Women

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Frequency of Antisperm Antibodies in Infertile Women

Nagar, West Tripura , India; moc. Sperm of humans, non-human primates, and other mammalian subjects is considered to be antigenic. The effect of changes in autoimmunity on reproductive cells such as spermatozoa and oocytes play a critical but indistinct role in fertility. Antisperm antibodies ASAs are invariably present in both females and males. However, the degree of ASA occurrence may vary according to individual and gender.
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Infertility is one of the common problems seen in couples of reproductive age. Presence of antisperm antibodies in semen and serum are amongst the causes of immunoinfertility. This study was performed to determine antisperm antibodies in cervicovaginal secretions and serum of infertile women and also measure serum levels of immunoglobulins IgG, IgM and IgA.
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Antisperm antibodies are antibodies produced against sperm antigens. ASA can be detected in ejaculate, cervical mucus, follicular fluid, and blood serum of both males and females. IgG occurring in genital tract fluids is either produced locally or transuded from blood serum, whereas IgA secretory type is always produced locally. ASA can arise whenever sperm encounter the immune system. However, these antibodies are also present in approximately 1—2.
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