They are usually associated with involuntary actions, including muscular spasms in multiple areas of the body, a general euphoric sensation and, frequently, body movements and vocalizations. Human orgasms usually result from physical sexual stimulation of the penis in males typically accompanying ejaculation and of the clitoris in females. The health effects surrounding the human orgasm are diverse. There are many physiological responses during sexual activity, including a relaxed state created by prolactin, as well as changes in the central nervous system such as a temporary decrease in the metabolic activity of large parts of the cerebral cortex while there is no change or increased metabolic activity in the limbic i. These effects affect cultural views of orgasm, such as the beliefs that orgasm and the frequency or consistency of it are either important or irrelevant for satisfaction in a sexual relationship,  and theories about the biological and evolutionary functions of orgasm. In a clinical context, orgasm is usually defined strictly by the muscular contractions involved during sexual activity, along with the characteristic patterns of change in heart rate, blood pressure, and often respiration rate and depth.
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27.5 Physiology of Arousal and Orgasm
Orgasm - Wikipedia
Although each specific condition can be separately defined in medical terms, clinically there is significant overlap in afflicted patients. The limited available data on female anatomy, physiology, biochemistry and molecular biology of the female sexual response makes this field particularly challenging to clinicians, psychologists and basic science researchers alike. The sexual response cycle consists of desire, arousal, orgasm and resolution both physiologic and psychologic. Desire is the mental state created by external and internal stimuli that induces a need or want to partake in sexual activity.
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The Physiology of Sexual Arousal in the Human Female: A Recreational and Procreational Synthesis
The following chapter will discuss the physiology of arousal and orgasm. Arousal includes the physiology of erection and increased lubrication production due to a combination of mental and physical stimuli. Orgasm typically includes the release of ejaculate and involuntary muscle contractions accompanied by feelings of euphoria.
Orgasm and ejaculation are two separate physiological processes that are sometimes difficult to distinguish. Orgasm is an intense transient peak sensation of intense pleasure creating an altered state of consciousness associated with reported physical changes. Antegrade ejaculation is a complex physiological process that is composed of two phases emission and expulsion , and is influenced by intricate neurological and hormonal pathways.