Mutations are the raw material of evolution, but have been difficult to study directly. We report the largest study of new mutations to date: 2, germline changes discovered by analyzing 85, Icelanders at 2, microsatellites. The paternal-to-maternal mutation rate ratio is 3. Longer microsatellite alleles are more mutagenic and tend to decrease in length, whereas the opposite is seen for shorter alleles.
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A direct characterization of human mutation based on microsatellites
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